Rationale, Design and Baseline Characteristics of Participants in the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) Trial.
Identifieur interne : 000488 ( Main/Exploration ); précédent : 000487; suivant : 000489Rationale, Design and Baseline Characteristics of Participants in the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) Trial.
Auteurs : Jackie Bosch [Canada] ; John W. Eikelboom [Canada] ; Stuart J. Connolly [Canada] ; Nancy Cook Bruns [Allemagne] ; Vivian Lanius [Allemagne] ; Fei Yuan [Canada] ; Frank Misselwitz [Allemagne] ; Edmond Chen [Allemagne] ; Rafael Diaz [Argentine] ; Marco Alings [Pays-Bas] ; Eva M. Lonn [Canada] ; Petr Widimsky [République tchèque] ; Masatsugu Hori [Japon] ; Alvaro Avezum [Brésil] ; Leopoldo S. Piegas [Brésil] ; Deepak L. Bhatt [États-Unis] ; Kelley R H. Branch [États-Unis] ; Jeffrey L. Probstfield [États-Unis] ; Yan Liang [République populaire de Chine] ; Lisheng Liu [République populaire de Chine] ; Jun Zhu [République populaire de Chine] ; Aldo P. Maggioni [Italie] ; Patricio Lopez-Jaramillo [Colombie] ; Martin O'Donnell [Irlande (pays)] ; Keith A A. Fox [Royaume-Uni] ; Ajay Kakkar [Royaume-Uni] ; Alexander N. Parkhomenko [Ukraine] ; Georg Ertl [Allemagne] ; Stefan Störk [Allemagne] ; Katalin Keltai [Hongrie] ; Matyas Keltai [Hongrie] ; Lars Ryden [Suède] ; Gilles R. Dagenais [Canada] ; Nana Pogosova [Russie] ; Antonio L. Dans ; Fernando Lanas [Chili] ; Patrick J. Commerford [Chili] ; Christian Torp-Pedersen [Danemark] ; Tomasz J. Guzik [Royaume-Uni] ; Peter B. Verhamme [Belgique] ; Dragos Vinereanu [Roumanie] ; Jae-Hyung Kim [Corée du Sud] ; Jong-Won Ha [Corée du Sud] ; Andrew M. Tonkin [Australie] ; John D. Varigos [Australie] ; Basil S. Lewis [Israël] ; Camilo Felix [Équateur] ; Khalid Yusoff [Malaisie] ; Philippe Gabriel Steg [France] ; Victor Aboyans [France] ; Kaj P. Metsarinne [Finlande] ; Sonia S. Anand [Canada] ; Robert G. Hart [Canada] ; Andre Lamy [Canada] ; Paul Moayyedi [Canada] ; Darryl P. Leong [Canada] ; Mukul Sharma [Canada] ; Salim Yusuf [Canada]Source :
- The Canadian journal of cardiology [ 1916-7075 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- normes : Traitement thrombolytique.
- usage thérapeutique : Anticoagulants.
- Essais contrôlés randomisés comme sujet, Guides de bonnes pratiques cliniques comme sujet, Humains, Maladies cardiovasculaires.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Anticoagulants.
- methods : Randomized Controlled Trials as Topic.
- prevention & control : Cardiovascular Diseases.
- standards : Thrombolytic Therapy.
- Humans, Practice Guidelines as Topic.
Abstract
Long-term aspirin prevents vascular events but is only modestly effective. Rivaroxaban alone or in combination with aspirin might be more effective than aspirin alone for vascular prevention in patients with stable coronary artery disease (CAD) or peripheral artery disease (PAD). Rivaroxaban as well as aspirin increase upper gastrointestinal (GI) bleeding and this might be prevented by proton pump inhibitor therapy.
DOI: 10.1016/j.cjca.2017.06.001
PubMed: 28754388
Affiliations:
- Allemagne, Argentine, Australie, Belgique, Brésil, Canada, Chili, Colombie, Corée du Sud, Danemark, Finlande, France, Hongrie, Irlande (pays), Israël, Italie, Japon, Malaisie, Pays-Bas, Roumanie, Royaume-Uni, Russie, République populaire de Chine, République tchèque, Suède, Ukraine, Équateur, États-Unis
- Angleterre, Bavière, Bohême centrale, District de Basse-Franconie, District fédéral central, Finlande occidentale, Grand Londres, Hongrie centrale, Hovedstaden, Limousin, Massachusetts, Nouvelle-Aquitaine, Région capitale de Séoul, Svealand, Utrecht (province), Victoria (État), Washington (État), Écosse, État de São Paulo, Île-de-France
- Budapest, Copenhague, Limoges, Londres, Melbourne, Moscou, Paris, Prague, Pékin, Seattle, Stockholm, São Paulo, Séoul, Turku, Utrecht, Wurtzbourg
- Université de São Paulo, Université de Washington
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Le document en format XML
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Lonn</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Widimsky, Petr" sort="Widimsky, Petr" uniqKey="Widimsky P" first="Petr" last="Widimsky">Petr Widimsky</name><affiliation wicri:level="3"><nlm:affiliation>Cardiocenter, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University Prague, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Cardiocenter, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University Prague, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Hori, Masatsugu" sort="Hori, Masatsugu" uniqKey="Hori M" first="Masatsugu" last="Hori">Masatsugu Hori</name><affiliation wicri:level="1"><nlm:affiliation>Osaka International Cancer Institute, Osaka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Osaka International Cancer Institute, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Avezum, Alvaro" sort="Avezum, Alvaro" uniqKey="Avezum A" first="Alvaro" last="Avezum">Alvaro Avezum</name><affiliation wicri:level="3"><nlm:affiliation>Instituto Dante Pazzanese de Cardiologia, Sao Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto Dante Pazzanese de Cardiologia, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Piegas, Leopoldo S" sort="Piegas, Leopoldo S" uniqKey="Piegas L" first="Leopoldo S" last="Piegas">Leopoldo S. Piegas</name><affiliation wicri:level="4"><nlm:affiliation>University of Sao Paulo, Sao Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>University of Sao Paulo, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Bhatt, Deepak L" sort="Bhatt, Deepak L" uniqKey="Bhatt D" first="Deepak L" last="Bhatt">Deepak L. Bhatt</name><affiliation wicri:level="2"><nlm:affiliation>Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Branch, Kelley R H" sort="Branch, Kelley R H" uniqKey="Branch K" first="Kelley R H" last="Branch">Kelley R H. Branch</name><affiliation wicri:level="2"><nlm:affiliation>University of Washington Medical Centre, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Washington Medical Centre, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Probstfield, Jeffrey L" sort="Probstfield, Jeffrey L" uniqKey="Probstfield J" first="Jeffrey L" last="Probstfield">Jeffrey L. Probstfield</name><affiliation wicri:level="4"><nlm:affiliation>University of Washington, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Liang, Yan" sort="Liang, Yan" uniqKey="Liang Y" first="Yan" last="Liang">Yan Liang</name><affiliation wicri:level="3"><nlm:affiliation>FuWai Hospital, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>FuWai Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Liu, Lisheng" sort="Liu, Lisheng" uniqKey="Liu L" first="Lisheng" last="Liu">Lisheng Liu</name><affiliation wicri:level="3"><nlm:affiliation>FuWai Hospital, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>FuWai Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhu, Jun" sort="Zhu, Jun" uniqKey="Zhu J" first="Jun" last="Zhu">Jun Zhu</name><affiliation wicri:level="3"><nlm:affiliation>FuWai Hospital, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>FuWai Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Maggioni, Aldo P" sort="Maggioni, Aldo P" uniqKey="Maggioni A" first="Aldo P" last="Maggioni">Aldo P. Maggioni</name><affiliation wicri:level="1"><nlm:affiliation>ANMCO Research Center, Florence, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>ANMCO Research Center, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Lopez Jaramillo, Patricio" sort="Lopez Jaramillo, Patricio" uniqKey="Lopez Jaramillo P" first="Patricio" last="Lopez-Jaramillo">Patricio Lopez-Jaramillo</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute, FOSCAL-Bucaramanga, Bucaramanga, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Research Institute, FOSCAL-Bucaramanga, Bucaramanga</wicri:regionArea><wicri:noRegion>Bucaramanga</wicri:noRegion></affiliation></author><author><name sortKey="O Donnell, Martin" sort="O Donnell, Martin" uniqKey="O Donnell M" first="Martin" last="O'Donnell">Martin O'Donnell</name><affiliation wicri:level="1"><nlm:affiliation>National University of Ireland, Galway, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>National University of Ireland, Galway</wicri:regionArea><wicri:noRegion>Galway</wicri:noRegion></affiliation></author><author><name sortKey="Fox, Keith A A" sort="Fox, Keith A A" uniqKey="Fox K" first="Keith A A" last="Fox">Keith A A. Fox</name><affiliation wicri:level="2"><nlm:affiliation>Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Écosse</region></placeName><wicri:cityArea>Centre for Cardiovascular Science, University of Edinburgh, Edinburgh</wicri:cityArea></affiliation></author><author><name sortKey="Kakkar, Ajay" sort="Kakkar, Ajay" uniqKey="Kakkar A" first="Ajay" last="Kakkar">Ajay Kakkar</name><affiliation wicri:level="3"><nlm:affiliation>University College London Hospitals, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London Hospitals, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Parkhomenko, Alexander N" sort="Parkhomenko, Alexander N" uniqKey="Parkhomenko A" first="Alexander N" last="Parkhomenko">Alexander N. Parkhomenko</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cardiology (Ukraine), Kiev, Ukraine.</nlm:affiliation><country xml:lang="fr">Ukraine</country><wicri:regionArea>Institute of Cardiology (Ukraine), Kiev</wicri:regionArea><wicri:noRegion>Kiev</wicri:noRegion></affiliation></author><author><name sortKey="Ertl, Georg" sort="Ertl, Georg" uniqKey="Ertl G" first="Georg" last="Ertl">Georg Ertl</name><affiliation wicri:level="3"><nlm:affiliation>Comprehensive Heart Failure Center University and University Hospital Würzburg, Würzburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Comprehensive Heart Failure Center University and University Hospital Würzburg, Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Stork, Stefan" sort="Stork, Stefan" uniqKey="Stork S" first="Stefan" last="Störk">Stefan Störk</name><affiliation wicri:level="3"><nlm:affiliation>Comprehensive Heart Failure Center University and University Hospital Würzburg, Würzburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Comprehensive Heart Failure Center University and University Hospital Würzburg, Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Keltai, Katalin" sort="Keltai, Katalin" uniqKey="Keltai K" first="Katalin" last="Keltai">Katalin Keltai</name><affiliation wicri:level="3"><nlm:affiliation>Semmelweis University, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Keltai, Matyas" sort="Keltai, Matyas" uniqKey="Keltai M" first="Matyas" last="Keltai">Matyas Keltai</name><affiliation wicri:level="3"><nlm:affiliation>Semmelweis University, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Ryden, Lars" sort="Ryden, Lars" uniqKey="Ryden L" first="Lars" last="Ryden">Lars Ryden</name><affiliation wicri:level="3"><nlm:affiliation>Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Dagenais, Gilles R" sort="Dagenais, Gilles R" uniqKey="Dagenais G" first="Gilles R" last="Dagenais">Gilles R. Dagenais</name><affiliation wicri:level="1"><nlm:affiliation>Institut Universitaire de Cardiologie et Pneumologie de Quebec, Quebec City, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institut Universitaire de Cardiologie et Pneumologie de Quebec, Quebec City, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Pogosova, Nana" sort="Pogosova, Nana" uniqKey="Pogosova N" first="Nana" last="Pogosova">Nana Pogosova</name><affiliation wicri:level="3"><nlm:affiliation>National Research Centre for Preventative Medicine (Moscow), Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>National Research Centre for Preventative Medicine (Moscow), Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Dans, Antonio L" sort="Dans, Antonio L" uniqKey="Dans A" first="Antonio L" last="Dans">Antonio L. Dans</name><affiliation><nlm:affiliation>University of Philippines - Manila, Manila, The Philippines.</nlm:affiliation><wicri:noCountry code="subField">The Philippines</wicri:noCountry></affiliation></author><author><name sortKey="Lanas, Fernando" sort="Lanas, Fernando" uniqKey="Lanas F" first="Fernando" last="Lanas">Fernando Lanas</name><affiliation wicri:level="1"><nlm:affiliation>Universidad de La Frontera, Temuco, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Universidad de La Frontera, Temuco</wicri:regionArea><wicri:noRegion>Temuco</wicri:noRegion></affiliation></author><author><name sortKey="Commerford, Patrick J" sort="Commerford, Patrick J" uniqKey="Commerford P" first="Patrick J" last="Commerford">Patrick J. Commerford</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cardiology, Department of Medicine, University of Cape Town, Temuco, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Division of Cardiology, Department of Medicine, University of Cape Town, Temuco</wicri:regionArea><wicri:noRegion>Temuco</wicri:noRegion></affiliation></author><author><name sortKey="Torp Pedersen, Christian" sort="Torp Pedersen, Christian" uniqKey="Torp Pedersen C" first="Christian" last="Torp-Pedersen">Christian Torp-Pedersen</name><affiliation wicri:level="3"><nlm:affiliation>University of Aalborg, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>University of Aalborg, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Guzik, Tomasz J" sort="Guzik, Tomasz J" uniqKey="Guzik T" first="Tomasz J" last="Guzik">Tomasz J. Guzik</name><affiliation wicri:level="1"><nlm:affiliation>Collegium Medicum Jagiellonian University, Krakow, Poland; University of Glasgow, Glasgow, Scotland, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Collegium Medicum Jagiellonian University, Krakow, Poland; University of Glasgow, Glasgow, Scotland</wicri:regionArea><wicri:noRegion>Scotland</wicri:noRegion></affiliation></author><author><name sortKey="Verhamme, Peter B" sort="Verhamme, Peter B" uniqKey="Verhamme P" first="Peter B" last="Verhamme">Peter B. Verhamme</name><affiliation wicri:level="1"><nlm:affiliation>University of Leuven, Flanders, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>University of Leuven, Flanders</wicri:regionArea><wicri:noRegion>Flanders</wicri:noRegion></affiliation></author><author><name sortKey="Vinereanu, Dragos" sort="Vinereanu, Dragos" uniqKey="Vinereanu D" first="Dragos" last="Vinereanu">Dragos Vinereanu</name><affiliation wicri:level="1"><nlm:affiliation>University of Medicine and Pharmacology Carol Davila University and Emergency Hospital, Bucharest, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>University of Medicine and Pharmacology Carol Davila University and Emergency Hospital, Bucharest</wicri:regionArea><wicri:noRegion>Bucharest</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Jae Hyung" sort="Kim, Jae Hyung" uniqKey="Kim J" first="Jae-Hyung" last="Kim">Jae-Hyung Kim</name><affiliation wicri:level="3"><nlm:affiliation>The Catholic University of Korea, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>The Catholic University of Korea, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Ha, Jong Won" sort="Ha, Jong Won" uniqKey="Ha J" first="Jong-Won" last="Ha">Jong-Won Ha</name><affiliation wicri:level="3"><nlm:affiliation>Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Tonkin, Andrew M" sort="Tonkin, Andrew M" uniqKey="Tonkin A" first="Andrew M" last="Tonkin">Andrew M. Tonkin</name><affiliation wicri:level="3"><nlm:affiliation>Monash University, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Varigos, John D" sort="Varigos, John D" uniqKey="Varigos J" first="John D" last="Varigos">John D. Varigos</name><affiliation wicri:level="3"><nlm:affiliation>Monash University, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Lewis, Basil S" sort="Lewis, Basil S" uniqKey="Lewis B" first="Basil S" last="Lewis">Basil S. Lewis</name><affiliation wicri:level="1"><nlm:affiliation>Lady Davis Carmel Medical Centre, Haifa, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Lady Davis Carmel Medical Centre, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Felix, Camilo" sort="Felix, Camilo" uniqKey="Felix C" first="Camilo" last="Felix">Camilo Felix</name><affiliation wicri:level="1"><nlm:affiliation>Facultad de Ciencias de la Salud Eugenio Espejo UTE, Quito, Ecuador.</nlm:affiliation><country xml:lang="fr">Équateur</country><wicri:regionArea>Facultad de Ciencias de la Salud Eugenio Espejo UTE, Quito</wicri:regionArea><wicri:noRegion>Quito</wicri:noRegion></affiliation></author><author><name sortKey="Yusoff, Khalid" sort="Yusoff, Khalid" uniqKey="Yusoff K" first="Khalid" last="Yusoff">Khalid Yusoff</name><affiliation wicri:level="1"><nlm:affiliation>Universiti Teknologi Mara, Selangor, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Universiti Teknologi Mara, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Steg, Philippe Gabriel" sort="Steg, Philippe Gabriel" uniqKey="Steg P" first="Philippe Gabriel" last="Steg">Philippe Gabriel Steg</name><affiliation wicri:level="3"><nlm:affiliation>Université Paris Diderot, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, FACT, DHU FIRE, INSERM U1148, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Diderot, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, FACT, DHU FIRE, INSERM U1148, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Aboyans, Victor" sort="Aboyans, Victor" uniqKey="Aboyans V" first="Victor" last="Aboyans">Victor Aboyans</name><affiliation wicri:level="3"><nlm:affiliation>Dupuytren University Hospital, Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Dupuytren University Hospital, Limoges</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Limousin</region><settlement type="city">Limoges</settlement></placeName></affiliation></author><author><name sortKey="Metsarinne, Kaj P" sort="Metsarinne, Kaj P" uniqKey="Metsarinne K" first="Kaj P" last="Metsarinne">Kaj P. Metsarinne</name><affiliation wicri:level="3"><nlm:affiliation>Turku University Central Hospital and Turku University, Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Turku University Central Hospital and Turku University, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Anand, Sonia S" sort="Anand, Sonia S" uniqKey="Anand S" first="Sonia S" last="Anand">Sonia S. Anand</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Hart, Robert G" sort="Hart, Robert G" uniqKey="Hart R" first="Robert G" last="Hart">Robert G. Hart</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Lamy, Andre" sort="Lamy, Andre" uniqKey="Lamy A" first="Andre" last="Lamy">Andre Lamy</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Moayyedi, Paul" sort="Moayyedi, Paul" uniqKey="Moayyedi P" first="Paul" last="Moayyedi">Paul Moayyedi</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Leong, Darryl P" sort="Leong, Darryl P" uniqKey="Leong D" first="Darryl P" last="Leong">Darryl P. Leong</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Mukul" sort="Sharma, Mukul" uniqKey="Sharma M" first="Mukul" last="Sharma">Mukul Sharma</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Yusuf, Salim" sort="Yusuf, Salim" uniqKey="Yusuf S" first="Salim" last="Yusuf">Salim Yusuf</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28754388</idno><idno type="pmid">28754388</idno><idno type="doi">10.1016/j.cjca.2017.06.001</idno><idno type="wicri:Area/PubMed/Corpus">000809</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000809</idno><idno type="wicri:Area/PubMed/Curation">000806</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000806</idno><idno type="wicri:Area/PubMed/Checkpoint">000806</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000806</idno><idno type="wicri:Area/Ncbi/Merge">004C02</idno><idno type="wicri:Area/Ncbi/Curation">004C02</idno><idno type="wicri:Area/Ncbi/Checkpoint">004C02</idno><idno type="wicri:Area/Main/Merge">000483</idno><idno type="wicri:Area/Main/Curation">000488</idno><idno type="wicri:Area/Main/Exploration">000488</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Rationale, Design and Baseline Characteristics of Participants in the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) Trial.</title><author><name sortKey="Bosch, Jackie" sort="Bosch, Jackie" uniqKey="Bosch J" first="Jackie" last="Bosch">Jackie Bosch</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada; School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada. Electronic address: jackie.bosch@phri.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada; School of Rehabilitation Science, McMaster University, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Eikelboom, John W" sort="Eikelboom, John W" uniqKey="Eikelboom J" first="John W" last="Eikelboom">John W. Eikelboom</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Connolly, Stuart J" sort="Connolly, Stuart J" uniqKey="Connolly S" first="Stuart J" last="Connolly">Stuart J. Connolly</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Bruns, Nancy Cook" sort="Bruns, Nancy Cook" uniqKey="Bruns N" first="Nancy Cook" last="Bruns">Nancy Cook Bruns</name><affiliation wicri:level="1"><nlm:affiliation>Bayer AG, Leverkusen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bayer AG, Leverkusen</wicri:regionArea><wicri:noRegion>Leverkusen</wicri:noRegion><wicri:noRegion>Leverkusen</wicri:noRegion><wicri:noRegion>Leverkusen</wicri:noRegion></affiliation></author><author><name sortKey="Lanius, Vivian" sort="Lanius, Vivian" uniqKey="Lanius V" first="Vivian" last="Lanius">Vivian Lanius</name><affiliation wicri:level="1"><nlm:affiliation>Bayer AG, Leverkusen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bayer AG, Leverkusen</wicri:regionArea><wicri:noRegion>Leverkusen</wicri:noRegion><wicri:noRegion>Leverkusen</wicri:noRegion><wicri:noRegion>Leverkusen</wicri:noRegion></affiliation></author><author><name sortKey="Yuan, Fei" sort="Yuan, Fei" uniqKey="Yuan F" first="Fei" last="Yuan">Fei Yuan</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Misselwitz, Frank" sort="Misselwitz, Frank" uniqKey="Misselwitz F" first="Frank" last="Misselwitz">Frank Misselwitz</name><affiliation wicri:level="1"><nlm:affiliation>Bayer AG, Leverkusen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bayer AG, Leverkusen</wicri:regionArea><wicri:noRegion>Leverkusen</wicri:noRegion><wicri:noRegion>Leverkusen</wicri:noRegion><wicri:noRegion>Leverkusen</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Edmond" sort="Chen, Edmond" uniqKey="Chen E" first="Edmond" last="Chen">Edmond Chen</name><affiliation wicri:level="1"><nlm:affiliation>Bayer AG, Leverkusen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bayer AG, Leverkusen</wicri:regionArea><wicri:noRegion>Leverkusen</wicri:noRegion><wicri:noRegion>Leverkusen</wicri:noRegion><wicri:noRegion>Leverkusen</wicri:noRegion></affiliation></author><author><name sortKey="Diaz, Rafael" sort="Diaz, Rafael" uniqKey="Diaz R" first="Rafael" last="Diaz">Rafael Diaz</name><affiliation wicri:level="1"><nlm:affiliation>Estudios Clínicos Latino América and Instituto Cardiovascular de Rosario, Rosario, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Estudios Clínicos Latino América and Instituto Cardiovascular de Rosario, Rosario</wicri:regionArea><wicri:noRegion>Rosario</wicri:noRegion></affiliation></author><author><name sortKey="Alings, Marco" sort="Alings, Marco" uniqKey="Alings M" first="Marco" last="Alings">Marco Alings</name><affiliation wicri:level="3"><nlm:affiliation>Amphia Ziekenhuis and WCN, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Amphia Ziekenhuis and WCN, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Lonn, Eva M" sort="Lonn, Eva M" uniqKey="Lonn E" first="Eva M" last="Lonn">Eva M. Lonn</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Widimsky, Petr" sort="Widimsky, Petr" uniqKey="Widimsky P" first="Petr" last="Widimsky">Petr Widimsky</name><affiliation wicri:level="3"><nlm:affiliation>Cardiocenter, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University Prague, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Cardiocenter, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University Prague, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Hori, Masatsugu" sort="Hori, Masatsugu" uniqKey="Hori M" first="Masatsugu" last="Hori">Masatsugu Hori</name><affiliation wicri:level="1"><nlm:affiliation>Osaka International Cancer Institute, Osaka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Osaka International Cancer Institute, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Avezum, Alvaro" sort="Avezum, Alvaro" uniqKey="Avezum A" first="Alvaro" last="Avezum">Alvaro Avezum</name><affiliation wicri:level="3"><nlm:affiliation>Instituto Dante Pazzanese de Cardiologia, Sao Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto Dante Pazzanese de Cardiologia, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Piegas, Leopoldo S" sort="Piegas, Leopoldo S" uniqKey="Piegas L" first="Leopoldo S" last="Piegas">Leopoldo S. Piegas</name><affiliation wicri:level="4"><nlm:affiliation>University of Sao Paulo, Sao Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>University of Sao Paulo, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Bhatt, Deepak L" sort="Bhatt, Deepak L" uniqKey="Bhatt D" first="Deepak L" last="Bhatt">Deepak L. Bhatt</name><affiliation wicri:level="2"><nlm:affiliation>Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Branch, Kelley R H" sort="Branch, Kelley R H" uniqKey="Branch K" first="Kelley R H" last="Branch">Kelley R H. Branch</name><affiliation wicri:level="2"><nlm:affiliation>University of Washington Medical Centre, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Washington Medical Centre, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Probstfield, Jeffrey L" sort="Probstfield, Jeffrey L" uniqKey="Probstfield J" first="Jeffrey L" last="Probstfield">Jeffrey L. Probstfield</name><affiliation wicri:level="4"><nlm:affiliation>University of Washington, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Liang, Yan" sort="Liang, Yan" uniqKey="Liang Y" first="Yan" last="Liang">Yan Liang</name><affiliation wicri:level="3"><nlm:affiliation>FuWai Hospital, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>FuWai Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Liu, Lisheng" sort="Liu, Lisheng" uniqKey="Liu L" first="Lisheng" last="Liu">Lisheng Liu</name><affiliation wicri:level="3"><nlm:affiliation>FuWai Hospital, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>FuWai Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhu, Jun" sort="Zhu, Jun" uniqKey="Zhu J" first="Jun" last="Zhu">Jun Zhu</name><affiliation wicri:level="3"><nlm:affiliation>FuWai Hospital, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>FuWai Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Maggioni, Aldo P" sort="Maggioni, Aldo P" uniqKey="Maggioni A" first="Aldo P" last="Maggioni">Aldo P. Maggioni</name><affiliation wicri:level="1"><nlm:affiliation>ANMCO Research Center, Florence, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>ANMCO Research Center, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Lopez Jaramillo, Patricio" sort="Lopez Jaramillo, Patricio" uniqKey="Lopez Jaramillo P" first="Patricio" last="Lopez-Jaramillo">Patricio Lopez-Jaramillo</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute, FOSCAL-Bucaramanga, Bucaramanga, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Research Institute, FOSCAL-Bucaramanga, Bucaramanga</wicri:regionArea><wicri:noRegion>Bucaramanga</wicri:noRegion></affiliation></author><author><name sortKey="O Donnell, Martin" sort="O Donnell, Martin" uniqKey="O Donnell M" first="Martin" last="O'Donnell">Martin O'Donnell</name><affiliation wicri:level="1"><nlm:affiliation>National University of Ireland, Galway, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>National University of Ireland, Galway</wicri:regionArea><wicri:noRegion>Galway</wicri:noRegion></affiliation></author><author><name sortKey="Fox, Keith A A" sort="Fox, Keith A A" uniqKey="Fox K" first="Keith A A" last="Fox">Keith A A. Fox</name><affiliation wicri:level="2"><nlm:affiliation>Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Écosse</region></placeName><wicri:cityArea>Centre for Cardiovascular Science, University of Edinburgh, Edinburgh</wicri:cityArea></affiliation></author><author><name sortKey="Kakkar, Ajay" sort="Kakkar, Ajay" uniqKey="Kakkar A" first="Ajay" last="Kakkar">Ajay Kakkar</name><affiliation wicri:level="3"><nlm:affiliation>University College London Hospitals, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London Hospitals, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Parkhomenko, Alexander N" sort="Parkhomenko, Alexander N" uniqKey="Parkhomenko A" first="Alexander N" last="Parkhomenko">Alexander N. Parkhomenko</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cardiology (Ukraine), Kiev, Ukraine.</nlm:affiliation><country xml:lang="fr">Ukraine</country><wicri:regionArea>Institute of Cardiology (Ukraine), Kiev</wicri:regionArea><wicri:noRegion>Kiev</wicri:noRegion></affiliation></author><author><name sortKey="Ertl, Georg" sort="Ertl, Georg" uniqKey="Ertl G" first="Georg" last="Ertl">Georg Ertl</name><affiliation wicri:level="3"><nlm:affiliation>Comprehensive Heart Failure Center University and University Hospital Würzburg, Würzburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Comprehensive Heart Failure Center University and University Hospital Würzburg, Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Stork, Stefan" sort="Stork, Stefan" uniqKey="Stork S" first="Stefan" last="Störk">Stefan Störk</name><affiliation wicri:level="3"><nlm:affiliation>Comprehensive Heart Failure Center University and University Hospital Würzburg, Würzburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Comprehensive Heart Failure Center University and University Hospital Würzburg, Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Keltai, Katalin" sort="Keltai, Katalin" uniqKey="Keltai K" first="Katalin" last="Keltai">Katalin Keltai</name><affiliation wicri:level="3"><nlm:affiliation>Semmelweis University, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Keltai, Matyas" sort="Keltai, Matyas" uniqKey="Keltai M" first="Matyas" last="Keltai">Matyas Keltai</name><affiliation wicri:level="3"><nlm:affiliation>Semmelweis University, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Ryden, Lars" sort="Ryden, Lars" uniqKey="Ryden L" first="Lars" last="Ryden">Lars Ryden</name><affiliation wicri:level="3"><nlm:affiliation>Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Dagenais, Gilles R" sort="Dagenais, Gilles R" uniqKey="Dagenais G" first="Gilles R" last="Dagenais">Gilles R. Dagenais</name><affiliation wicri:level="1"><nlm:affiliation>Institut Universitaire de Cardiologie et Pneumologie de Quebec, Quebec City, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institut Universitaire de Cardiologie et Pneumologie de Quebec, Quebec City, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Pogosova, Nana" sort="Pogosova, Nana" uniqKey="Pogosova N" first="Nana" last="Pogosova">Nana Pogosova</name><affiliation wicri:level="3"><nlm:affiliation>National Research Centre for Preventative Medicine (Moscow), Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>National Research Centre for Preventative Medicine (Moscow), Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Dans, Antonio L" sort="Dans, Antonio L" uniqKey="Dans A" first="Antonio L" last="Dans">Antonio L. Dans</name><affiliation><nlm:affiliation>University of Philippines - Manila, Manila, The Philippines.</nlm:affiliation><wicri:noCountry code="subField">The Philippines</wicri:noCountry></affiliation></author><author><name sortKey="Lanas, Fernando" sort="Lanas, Fernando" uniqKey="Lanas F" first="Fernando" last="Lanas">Fernando Lanas</name><affiliation wicri:level="1"><nlm:affiliation>Universidad de La Frontera, Temuco, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Universidad de La Frontera, Temuco</wicri:regionArea><wicri:noRegion>Temuco</wicri:noRegion></affiliation></author><author><name sortKey="Commerford, Patrick J" sort="Commerford, Patrick J" uniqKey="Commerford P" first="Patrick J" last="Commerford">Patrick J. Commerford</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cardiology, Department of Medicine, University of Cape Town, Temuco, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Division of Cardiology, Department of Medicine, University of Cape Town, Temuco</wicri:regionArea><wicri:noRegion>Temuco</wicri:noRegion></affiliation></author><author><name sortKey="Torp Pedersen, Christian" sort="Torp Pedersen, Christian" uniqKey="Torp Pedersen C" first="Christian" last="Torp-Pedersen">Christian Torp-Pedersen</name><affiliation wicri:level="3"><nlm:affiliation>University of Aalborg, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>University of Aalborg, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Guzik, Tomasz J" sort="Guzik, Tomasz J" uniqKey="Guzik T" first="Tomasz J" last="Guzik">Tomasz J. Guzik</name><affiliation wicri:level="1"><nlm:affiliation>Collegium Medicum Jagiellonian University, Krakow, Poland; University of Glasgow, Glasgow, Scotland, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Collegium Medicum Jagiellonian University, Krakow, Poland; University of Glasgow, Glasgow, Scotland</wicri:regionArea><wicri:noRegion>Scotland</wicri:noRegion></affiliation></author><author><name sortKey="Verhamme, Peter B" sort="Verhamme, Peter B" uniqKey="Verhamme P" first="Peter B" last="Verhamme">Peter B. Verhamme</name><affiliation wicri:level="1"><nlm:affiliation>University of Leuven, Flanders, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>University of Leuven, Flanders</wicri:regionArea><wicri:noRegion>Flanders</wicri:noRegion></affiliation></author><author><name sortKey="Vinereanu, Dragos" sort="Vinereanu, Dragos" uniqKey="Vinereanu D" first="Dragos" last="Vinereanu">Dragos Vinereanu</name><affiliation wicri:level="1"><nlm:affiliation>University of Medicine and Pharmacology Carol Davila University and Emergency Hospital, Bucharest, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>University of Medicine and Pharmacology Carol Davila University and Emergency Hospital, Bucharest</wicri:regionArea><wicri:noRegion>Bucharest</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Jae Hyung" sort="Kim, Jae Hyung" uniqKey="Kim J" first="Jae-Hyung" last="Kim">Jae-Hyung Kim</name><affiliation wicri:level="3"><nlm:affiliation>The Catholic University of Korea, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>The Catholic University of Korea, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Ha, Jong Won" sort="Ha, Jong Won" uniqKey="Ha J" first="Jong-Won" last="Ha">Jong-Won Ha</name><affiliation wicri:level="3"><nlm:affiliation>Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Tonkin, Andrew M" sort="Tonkin, Andrew M" uniqKey="Tonkin A" first="Andrew M" last="Tonkin">Andrew M. Tonkin</name><affiliation wicri:level="3"><nlm:affiliation>Monash University, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Varigos, John D" sort="Varigos, John D" uniqKey="Varigos J" first="John D" last="Varigos">John D. Varigos</name><affiliation wicri:level="3"><nlm:affiliation>Monash University, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Lewis, Basil S" sort="Lewis, Basil S" uniqKey="Lewis B" first="Basil S" last="Lewis">Basil S. Lewis</name><affiliation wicri:level="1"><nlm:affiliation>Lady Davis Carmel Medical Centre, Haifa, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Lady Davis Carmel Medical Centre, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Felix, Camilo" sort="Felix, Camilo" uniqKey="Felix C" first="Camilo" last="Felix">Camilo Felix</name><affiliation wicri:level="1"><nlm:affiliation>Facultad de Ciencias de la Salud Eugenio Espejo UTE, Quito, Ecuador.</nlm:affiliation><country xml:lang="fr">Équateur</country><wicri:regionArea>Facultad de Ciencias de la Salud Eugenio Espejo UTE, Quito</wicri:regionArea><wicri:noRegion>Quito</wicri:noRegion></affiliation></author><author><name sortKey="Yusoff, Khalid" sort="Yusoff, Khalid" uniqKey="Yusoff K" first="Khalid" last="Yusoff">Khalid Yusoff</name><affiliation wicri:level="1"><nlm:affiliation>Universiti Teknologi Mara, Selangor, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Universiti Teknologi Mara, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Steg, Philippe Gabriel" sort="Steg, Philippe Gabriel" uniqKey="Steg P" first="Philippe Gabriel" last="Steg">Philippe Gabriel Steg</name><affiliation wicri:level="3"><nlm:affiliation>Université Paris Diderot, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, FACT, DHU FIRE, INSERM U1148, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Diderot, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, FACT, DHU FIRE, INSERM U1148, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Aboyans, Victor" sort="Aboyans, Victor" uniqKey="Aboyans V" first="Victor" last="Aboyans">Victor Aboyans</name><affiliation wicri:level="3"><nlm:affiliation>Dupuytren University Hospital, Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Dupuytren University Hospital, Limoges</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Limousin</region><settlement type="city">Limoges</settlement></placeName></affiliation></author><author><name sortKey="Metsarinne, Kaj P" sort="Metsarinne, Kaj P" uniqKey="Metsarinne K" first="Kaj P" last="Metsarinne">Kaj P. Metsarinne</name><affiliation wicri:level="3"><nlm:affiliation>Turku University Central Hospital and Turku University, Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Turku University Central Hospital and Turku University, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Anand, Sonia S" sort="Anand, Sonia S" uniqKey="Anand S" first="Sonia S" last="Anand">Sonia S. Anand</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Hart, Robert G" sort="Hart, Robert G" uniqKey="Hart R" first="Robert G" last="Hart">Robert G. Hart</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Lamy, Andre" sort="Lamy, Andre" uniqKey="Lamy A" first="Andre" last="Lamy">Andre Lamy</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Moayyedi, Paul" sort="Moayyedi, Paul" uniqKey="Moayyedi P" first="Paul" last="Moayyedi">Paul Moayyedi</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Leong, Darryl P" sort="Leong, Darryl P" uniqKey="Leong D" first="Darryl P" last="Leong">Darryl P. Leong</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Mukul" sort="Sharma, Mukul" uniqKey="Sharma M" first="Mukul" last="Sharma">Mukul Sharma</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Yusuf, Salim" sort="Yusuf, Salim" uniqKey="Yusuf S" first="Salim" last="Yusuf">Salim Yusuf</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Canadian journal of cardiology</title><idno type="eISSN">1916-7075</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anticoagulants (therapeutic use)</term><term>Cardiovascular Diseases (prevention & control)</term><term>Humans</term><term>Practice Guidelines as Topic</term><term>Randomized Controlled Trials as Topic (methods)</term><term>Thrombolytic Therapy (standards)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticoagulants (usage thérapeutique)</term><term>Essais contrôlés randomisés comme sujet ()</term><term>Guides de bonnes pratiques cliniques comme sujet</term><term>Humains</term><term>Maladies cardiovasculaires ()</term><term>Traitement thrombolytique (normes)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anticoagulants</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Randomized Controlled Trials as Topic</term></keywords><keywords scheme="MESH" qualifier="normes" xml:lang="fr"><term>Traitement thrombolytique</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Cardiovascular Diseases</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Thrombolytic Therapy</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticoagulants</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Practice Guidelines as Topic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Essais contrôlés randomisés comme sujet</term><term>Guides de bonnes pratiques cliniques comme sujet</term><term>Humains</term><term>Maladies cardiovasculaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Long-term aspirin prevents vascular events but is only modestly effective. Rivaroxaban alone or in combination with aspirin might be more effective than aspirin alone for vascular prevention in patients with stable coronary artery disease (CAD) or peripheral artery disease (PAD). Rivaroxaban as well as aspirin increase upper gastrointestinal (GI) bleeding and this might be prevented by proton pump inhibitor therapy.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Argentine</li><li>Australie</li><li>Belgique</li><li>Brésil</li><li>Canada</li><li>Chili</li><li>Colombie</li><li>Corée du Sud</li><li>Danemark</li><li>Finlande</li><li>France</li><li>Hongrie</li><li>Irlande (pays)</li><li>Israël</li><li>Italie</li><li>Japon</li><li>Malaisie</li><li>Pays-Bas</li><li>Roumanie</li><li>Royaume-Uni</li><li>Russie</li><li>République populaire de Chine</li><li>République tchèque</li><li>Suède</li><li>Ukraine</li><li>Équateur</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bavière</li><li>Bohême centrale</li><li>District de Basse-Franconie</li><li>District fédéral central</li><li>Finlande occidentale</li><li>Grand Londres</li><li>Hongrie centrale</li><li>Hovedstaden</li><li>Limousin</li><li>Massachusetts</li><li>Nouvelle-Aquitaine</li><li>Région capitale de Séoul</li><li>Svealand</li><li>Utrecht (province)</li><li>Victoria (État)</li><li>Washington (État)</li><li>Écosse</li><li>État de São Paulo</li><li>Île-de-France</li></region><settlement><li>Budapest</li><li>Copenhague</li><li>Limoges</li><li>Londres</li><li>Melbourne</li><li>Moscou</li><li>Paris</li><li>Prague</li><li>Pékin</li><li>Seattle</li><li>Stockholm</li><li>São Paulo</li><li>Séoul</li><li>Turku</li><li>Utrecht</li><li>Wurtzbourg</li></settlement><orgName><li>Université de São Paulo</li><li>Université de Washington</li></orgName></list><tree><noCountry><name sortKey="Dans, Antonio L" sort="Dans, Antonio L" uniqKey="Dans A" first="Antonio L" last="Dans">Antonio L. Dans</name></noCountry><country name="Canada"><noRegion><name sortKey="Bosch, Jackie" sort="Bosch, Jackie" uniqKey="Bosch J" first="Jackie" last="Bosch">Jackie Bosch</name></noRegion><name sortKey="Anand, Sonia S" sort="Anand, Sonia S" uniqKey="Anand S" first="Sonia S" last="Anand">Sonia S. Anand</name><name sortKey="Connolly, Stuart J" sort="Connolly, Stuart J" uniqKey="Connolly S" first="Stuart J" last="Connolly">Stuart J. Connolly</name><name sortKey="Dagenais, Gilles R" sort="Dagenais, Gilles R" uniqKey="Dagenais G" first="Gilles R" last="Dagenais">Gilles R. Dagenais</name><name sortKey="Eikelboom, John W" sort="Eikelboom, John W" uniqKey="Eikelboom J" first="John W" last="Eikelboom">John W. Eikelboom</name><name sortKey="Hart, Robert G" sort="Hart, Robert G" uniqKey="Hart R" first="Robert G" last="Hart">Robert G. Hart</name><name sortKey="Lamy, Andre" sort="Lamy, Andre" uniqKey="Lamy A" first="Andre" last="Lamy">Andre Lamy</name><name sortKey="Leong, Darryl P" sort="Leong, Darryl P" uniqKey="Leong D" first="Darryl P" last="Leong">Darryl P. Leong</name><name sortKey="Lonn, Eva M" sort="Lonn, Eva M" uniqKey="Lonn E" first="Eva M" last="Lonn">Eva M. 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Metsarinne</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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